El SueƱo de la Razon Produce Monstruos
(The Sleep of Reason Brings Forth Monsters)
Francisco Goya
Fish, as is well known, sleep while swimming. This sounds like a really good trick to learn, especially right now.
I wrote something else last night around 3:00AM that I was going to post today, but as I drove home close to noon I realized that what's really on my mind at the moment is sleep, its absence, and how I feel about all of that. I've been provided with a natural opportunity for reflection on this (in my capacity as experiment of nature) in that as I write, I am cementing a strong lead in the race for my Most Extreme Work to Sleep Ratio: out of the last seventy-five hours I have slept about ten. I got up on Tuesday morning, worked a full day in the ICU, then covered the medicine wards until Wednesday morning, when I went back to the ICU to see my regular patients. Then I went home around noon, tried to have a day (not an especially ambitious one, just a day not spent in the hospital) went to bed around eleven. I worked Thursday morning in the ICU, and spent the afternoon in my primary care clinic. I stayed on overnight, again covering the medical wards, and after an eventful morning in the ICU I am now home, coming up on hour seventy-six. My cats have disappeared. I suspect that they have given up on me, and struck out for someplace where the streets are paved with moths and by-catch; a place where with a with a little bit of hard work and a dream, a cat can make something of itself.
The scary thing is that this sort of thing isn't actually that uncommon in the United States. In my residency program it's rare to do every second day on call like this - I actually did this deliberately, in order to avoid a scheduled night on call next week. At some hospitals (although this is increasingly rare) housestaff are deliberately put on call every third night, although usually it's a team of junior doctors. My hospital, with some audacity, leaves it to one intern who has already worked a full day to cover four wards and an intensive care unit. There is also a second or third year resident at night, but they're usually busy helping admit patients from the emergency room or consulting on surgical patients with medical problems. The chain of referral, in any case, starts with the intern who can then decide to call their resident if they feel the situation is beyond their competence. This means the intern's pager goes off, at best, every twenty minutes and at worst almost continuously. This is not compatible with restful sleep. Moreover, (this has happened to me twice now) if you do try to sleep it's always right when you're drifting into REM that you get a call about someone who sounds actually, properly sick and whom you definitely need to go evaluate personally. This is an awful feeling. Not only is it physically unpleasant to be woken up from a fitful nap on a hospital cot by a screeching pager, it's very scary to be asked to make important medical decisions when you are barely awake. I don't even try to sleep anymore, because both of the times I did it I was called from my bed to evaluate somebody who was moving towards septic shock, something that needs to be approached with decisive intelligence even by the well-rested.
A great deal of research has been done on the effects of this kind of sleep deprivation, much of it conducted
specifically on doctors in training, since we are an ideal cohort to study, along with PhD students, truck drivers, and soldiers. Overwhelmingly, this research hows that significant decrements in one's ability to think clearly about medicine increase proportionally to the number of hours without sleep. This brings to mind a friend of mine's characterization of sociology as "banal insights into the blatantly obvious". Personally, I think that succinctly describes at least this observation, but in case you're curious one prospective study published in the New England Journal of Medicine in 2004 compared two groups of interns, one working on a call schedule which required thirty-hour shifts every third night and one working on in more conventional shifts. The authors found that the "traditional" group made over fifty percent more "nonintercepted" serious medical errors than the experimental group, and twenty-two percent more serious errors overall - which is to say, the screwed up much more often, and their mistakes were far less frequently caught before they actually damaged someone.
I find it striking that a bunch of highly educated people all of whom had been through medical residency thought that they needed to organize a prospective trial to prove this. Or, to be slightly more cynical, I find it a rather sinister indication of the
status quo's tenacity that they should have to marshal this kind of investigative firepower to prove the intuitively obvious point that the best person to handle an urgent situation involving the possibility of death or permanent disability is
not the one who's just fallen asleep after, say, twenty hours of continuous work.
Not, I would hasten to add, that this study or others like it managed to change much, at least here. The American Council for Graduate Medical Education recently adopted some self-imposed rules (e.g. the 80-hour week, the 30-hour maximum continuous duty period, the requirement of one day off every week averaged over four weeks,) which mildly ameliorated the situation, but are pretty obviously aimed at obviating legal regulation, not at creating a well-rested workforce. I have a friend from medical school now working in England who tells me that for every night he works he gets not only the subsequent day off, but also an entirely separate day, with its attendant night. When I tell American residents about this the responses are usually notable for their creative deployment of astonished profanity.
Last night, at a sleep-hour to wake-hour ratio of around 9:53, I was called to see a patient, (let's call him Mr. I,) in the transitional care unit, (which is the low-calorie version of the intensive care unit,) who was having trouble breathing. Mr. I is a big man in his early forties with severe lung disease and right-sided heart failure, who is trying desperately to get on a heart-lung transplant list. (In fact, he was brought in by an ambulance
from the airport where he was about to board a flight to Vanderbilt to be assessed for surgery. I should write Alanis Morisette with this story - maybe the royalties from the resulting hit single would pay for his operation.) Anyway, I went through his chart and lab records in some detail, and by the time I was done writing orders I was feeling pretty good about myself. I had come up with a systematic plan to stabilize him, organ-system by organ-system, and I was also pretty sure I had identified a major flaw in the clinical reasoning that had been applied to the case so far. I realized that I could improve his breathing significantly just by giving him an intravenous infusion of fluid, (this will probably sound stupid if you're used to dealing with heart failure, but in his case it made sense. Full explanation available upon request), without having to transfer him to the ICU or put in a central venous line or intubate him or anything dramatic and unpleasant like that. This isn't, by the way, any kind of comment on the day team - they had many other patients who required an equal amount of attention and the course they pursued was a pretty standard and reasonable one. I just happened to be called at an ebb in the perpetual pager-storm when I could actually concentrate on the case, and I had a fresh pair of eyes and records of everything they'd done and every test result they'd gotten in front of me all at once.
The rest of the night was comparatively reasonable, relative to some of my worse experiences on call. There were periods of, oh, fifteen minutes when my pager didn't go off at all, and when I was called it was mainly for minor things I could handle over the phone. I even had time to do a little reading. I pulled up a few articles on sleep deprivation - it seemed topical. I was not called to see Mr. I again.
When morning finally came I was beginning to flag. I can always tell when physiological exhaustion is setting in because I start losing my short term memory and become increasingly dependent on notes. I wrote up the morning lab reports and overnight vitals for my one ICU patient, came up with a plan of action for her, and wandered down to Grand Rounds, the Friday Department of Medicine morning lecture, to see if some free bagels and omega-3 rich smoked salmon spread would improve my failing higher faculties.
This is where the whole thing devolved into a sort of hallucinatory nightmare.
The Grand Rounds lecture is given in part of the old hospital building where there's no overhead intercom system. This is relevant because that's one of the ways the hospital operators announce medical emergencies, which all members of the ICU team are supposed to attend to whenever they're in the hospital. We were all at the lecture - however, of the four interns, two residents, and one attending physician, least three of us always carry "code pagers" which are little walkie-talkies that are supposed
to emit a shrieking noise whenever there's a major medical emergency, (or "code blue") followed by an announcement of its location. Theoretically, then, we shouldn't need to be in earshot of the PA system to know when there's a code. For some reason, which I have insistently pursued without any success, despite enhanced interrogation techniques, there is often a failure to communicate between the operators who announce code blues and the pagers. This fact never loses its novelty for me, since it is transparently imperative that the code pagers work reliably; they are, after all, probably the only pagers in the hospital on which life and death may actually hinge. As you must have already guessed from all the bitter asides, there
was a code blue, and not a single one of them went off. We heard about it by word of mouth, which is a totally moronic way to convey this kind of information. Pagers were invented in the first place so that people who need to know things immediately, like doctors and crack dealers, could circumvent exactly this problem.
I have to confess that my first thought was,
Shit. There goes my ten O'clock exit visa. My second thought was also
Shit, because the code had been called in Mr. I's room. The gentleman I had been feeling so chuffed about having managed in such a systematic and creative way the night before. Mr. I, who I hadn't transferred to the ICU because I'd been confident he would be fine in the TCU. Mr. I, who I was pretty sure just needed a little more intravascular volume to enhance his right ventricular pre-load, and was definitely, definitely, not going to be emergently intubated or go into ventricular fibrillation or otherwise explode.
Shit, I thought,
I'm a statistic. I haven't slept enough, and I just committed a major, nonintercepted medical error. I screwed up something crucial last night which I would have gotten right if I had been more awake, and now he's going to die. Shit.
The scene which evolved when we arrived was horrendous, and only made more so by a persistently farcical which quickly developed. Mr. I was lying on his back on the bed, his eyes rolling dysynchronously. He was being ventilated by an Emergency Department resident with a bag-and-mask apparatus. Apparently, he had been returning from the bathroom and had collapsed on his bed, unresponsive.
Codes are supposed to be swift, decisive, methodical, and run according to evidence-based and generally known algorithms.
They are like this to some extent, but usually the first five minutes (which are obviously the most important ones) are pretty chaotic. Everyone within three floors comes running and crowds into the room. The problem is usually that it's not entirely clear who's in command. Technically it's the medical resident on call, but most of our medical residents feel diffident about assuming responsibility because the emergency room residents are much more experienced. The ED residents know this and many of them try to politely defer. The attending usually cuts through the chaos to demand that absolutely imperative things like attaching defibrillators and blood pressure monitors happen, but they also usually try to induce a resident to assume control - so there's often this awkward few minutes where it's not entirely clear who's in charge or what order things are supposed to happen in, and so everything starts happening at once while the attending, the medicine resident, and the emergency resident engage in the medical crisis version of "I insist," "Oh no, I insist," "No, no, after you," "Oh no, I couldn't possibly," etc. The defibrillator is attached, and there's a frenzy of flying needles as people try to insert large-bore lines into any vessel they can see or feel. At the head of the bed there's a running conversation about how the bagging is going and whether we're going to intubate, while at the foot there's an independent debate about the rhythm on the monitor, and somebody is loudly demanding to know where that blood pressure cuff is, while someone else is yelling for a central line kit, and yet another person is trying to figure out if they should be starting chest compressions. Eventually somebody assumes command, and things become slightly more systematic and fall into a recognizable resuscitation algorithm. At this point, people get bored and drift out, and things become slightly more manageable. This code, however, was more hectic than most. First there was an incredibly ambivalent debate about whether or not Mr. I in fact had a pulse to go with the electrical activity on the monitor. Nobody, including me, could be absolutely sure. Then it emerged that the crash-cart, which is supposed to have all the stuff you need in it, was missing all kinds of things - sterlizing scrubs, sutures, etc., and there was a mad exodus of residents pelting down to nursing stations at either end of the building to search desperately for the right kind of suture or an extra arterial blood gas kit. The problem is that all the wards, for mysterious reasons, have their own budgets and are therefore reflexively defensive of their supplies - this habit of mind is so ingrained that even when I sprinted into the nursing station of an adjacent ward to requisition some minor antiseptic products, saying breathlessly, "Quick, it's for the code!" the clerk gave me a look of disgusted persecution and whined, "Don't they have that stuff on TCU?"
And then the room flooded. I got back just as my immediate senior, who had been the resident on-call the night before and slept only a few hours more than I did was putting a central line into Mr. I's femoral vein. The line splits at the end into three tributaries, and you have to fill them with water so that when you inject into them you don't shoot air bubbles into the patient's circulation.
"Flush," she said, "I need a flush."
I grabbed a few syringes of saline and started emptying them into the central line tray so she could draw them up with a sterile syringe. Behind me, someone said "Jesus, what's all this water?"
"It's just saline," I said, "for the line."
"Really?" she replied. Then I realized that somebody had put the intubation tray on the sink, which had pushed the cold water tap on, and that it had been running onto a towel which was blocking the drain for several minutes. We were all standing in an inch of bloody water.
And, naturally, as all this was going on, I was dredging my increasingly dysfunctional memory, trying to fiture out which part of the brilliant plan I had formulated the night before had contained the moronic oversight which was going to turn out to have caused this absurd, deadly situation.
..................................
I like to think that I would still be telling this story had the whole thing actually been my fault. Reviewing what I did afterwards with some older doctors, it appears, mercifully, that I was right; it was a good plan, and it probably averted a slow decline towards respiratory failure. It looks, at this point, like whatever happened was a sudden and unpredictable event, (probably a pulmonary embolism,) which I definitely had nothing to do with and may have even delayed. Mr. I. was stable in the ICU when I finally left around eleven, receiving empiric therapy for his presumed PE. Unfortunately he is too large for any of our scanners, (an increasingly frequent problem, for which the radiology technicians have no sympathy whatever since somebody cajoled them to accept a patient over the scanner table's weight rating and the table promptly broke) so we won't know exactly what happened until (or rather, unless) we can deduce it from his clinical course and some indirect testing.
It is nice to be fairly assured that I'm not (yet) the author of a "nonintercepted" serious medical error - although, like a smoker with unexpectedly normal lung function tests, I have to fight the consequent impulse to assume that I'm somehow an exception, that the formula which relates sleep deprivation to misdiagnosis, inappropriate treatment, and simple mistakes somehow doesn't apply to me. And who knows - maybe if I had slept more in the last few days I would have seen something last night which would have allowed me to predict and avert this.
Fish, as is well known, sleep while swimming. This is because fish are stupid and the scope of their professional lives outside of the closely circumscribed fields of sex and predation is basically insignificant. Also, they have developed such that in order
simply not to swim, they have to be dead. Even then there is some gray area. I recently caught a fish which, as is standard practice in these matters, I hit on the back of its head with the blunt side of a hunting knife until it had no apparent reserves of centrally controlled executive or automatic function, even within the stunningly narrow ambit of quotidian fishy activity. Its gills ceased to move. Its cold, clammy little heart lay still in its slimy breast. It's gooey brain ceased to issue programmatic statements on the laying of eggs and eating of bugs. I left it on the river bank and went looking for other places to catch fish, and when I returned, it was gone. I found it after a few minutes of searching (it was a big fish) lying in the shallows on its side, dead, its tail twitching as motor complexes hard-wired into its spinal cord burned through their last reserves of energy.
So bollocks to the fish. I breathe when I sleep, and sometimes I move a limb aimlessly, which is about as impressive as sleeping fish swimming - i.e., not very impressive at all. When I am not sleeping, however, I enjoy my membership in a species of highly complicated mammal, and the privileges which inhere therein. These include, but not limited to the pursuit of elaborate, elegant non-genetic structures of cognition and discourse like music, language, art, and medicine. And if I'm going to participate in these at the level to which I aspire, I need a little more sleep.
Good night.